It is a great honor to be asked to write a memoriam for Dr. Jack H. Wilmore. Dr. Wilmore was my doctoral mentor, my friend, and most importantly, my brother in Christ. Dr. Wilmore's impact on both exercise physiology and clinical exercise physiology over his long career was extensive and far reaching. Dr. Wilmore was a past-president of the American College of Sports Medicine (ACSM; 1978–79). Based on an extensive career (317 peer-reviewed research articles; 55 chapters in edited books; 15 authored/co-authored books; research grants from the National Institutes of Health, National Aeronautics and Space Administration (NASA), and the United